The psoriasis-associated deletion of late cornified envelope genes LCE3B and LCE3C has been maintained under balancing selection since Human Denisovan divergence

BACKGROUND: A common, 32kb deletion of LCE3B and LCE3C genes is strongly associated with psoriasis. We recently found that this deletion is ancient, predating Human-Denisovan divergence. However, it was not clear why negative selection has not removed this deletion from the population. RESULTS: Here...

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Detalles Bibliográficos
Autores principales: Pajic, Petar, Lin, Yen-Lung, Xu, Duo, Gokcumen, Omer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139038/
https://www.ncbi.nlm.nih.gov/pubmed/27919236
http://dx.doi.org/10.1186/s12862-016-0842-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139038/
https://www.ncbi.nlm.nih.gov/pubmed/27919236
http://dx.doi.org/10.1186/s12862-016-0842-6

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