Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors

BACKGROUND: Blocking the mechanistic target of rapamycin complex-1 (mTORC1) with chemical inhibitors such as rapamycin has shown limited clinical efficacy in cancer. The tumor microenvironment is characterized by an acidic pH which interferes with cancer therapies. The consequences of acidity on the...

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Detalles Bibliográficos
Autores principales: Faes, Seraina, Duval, Adrian P., Planche, Anne, Uldry, Emilie, Santoro, Tania, Pythoud, Catherine, Stehle, Jean-Christophe, Horlbeck, Janine, Letovanec, Igor, Riggi, Nicolo, Demartines, Nicolas, Dormond, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139076/
https://www.ncbi.nlm.nih.gov/pubmed/27919264
http://dx.doi.org/10.1186/s12943-016-0562-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139076/
https://www.ncbi.nlm.nih.gov/pubmed/27919264
http://dx.doi.org/10.1186/s12943-016-0562-y

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