Cargando…
Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors
BACKGROUND: Blocking the mechanistic target of rapamycin complex-1 (mTORC1) with chemical inhibitors such as rapamycin has shown limited clinical efficacy in cancer. The tumor microenvironment is characterized by an acidic pH which interferes with cancer therapies. The consequences of acidity on the...
Autores principales: | Faes, Seraina, Duval, Adrian P., Planche, Anne, Uldry, Emilie, Santoro, Tania, Pythoud, Catherine, Stehle, Jean-Christophe, Horlbeck, Janine, Letovanec, Igor, Riggi, Nicolo, Demartines, Nicolas, Dormond, Olivier |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139076/ https://www.ncbi.nlm.nih.gov/pubmed/27919264 http://dx.doi.org/10.1186/s12943-016-0562-y |
Ejemplares similares
-
Targeting carbonic anhydrase IX improves the anti-cancer efficacy of mTOR inhibitors
por: Faes, Seraina, et al.
Publicado: (2016) -
Acidic pH reduces VEGF-mediated endothelial cell responses by downregulation of VEGFR-2; relevance for anti-angiogenic therapies
por: Faes, Seraina, et al.
Publicado: (2016) -
Resistance to mTORC1 Inhibitors in Cancer Therapy: From Kinase Mutations to Intratumoral Heterogeneity of Kinase Activity
por: Faes, Seraina, et al.
Publicado: (2017) -
Fine-Tuning Tumor Endothelial Cells to Selectively Kill Cancer
por: Uldry, Emilie, et al.
Publicado: (2017) -
Evolving Significance and Future Relevance of Anti-Angiogenic Activity of mTOR Inhibitors in Cancer Therapy
por: Faes, Seraina, et al.
Publicado: (2017)