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A Novel Rrm3 Function in Restricting DNA Replication via an Orc5-Binding Domain Is Genetically Separable from Rrm3 Function as an ATPase/Helicase in Facilitating Fork Progression

In response to replication stress cells activate the intra-S checkpoint, induce DNA repair pathways, increase nucleotide levels, and inhibit origin firing. Here, we report that Rrm3 associates with a subset of replication origins and controls DNA synthesis during replication stress. The N-terminal d...

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Detalles Bibliográficos
Autores principales: Syed, Salahuddin, Desler, Claus, Rasmussen, Lene J., Schmidt, Kristina H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140057/
https://www.ncbi.nlm.nih.gov/pubmed/27923055
http://dx.doi.org/10.1371/journal.pgen.1006451