Oxidative guanine base damage regulates human telomerase activity

Changes in telomere length are associated with degenerative diseases and cancer. Oxidative stress and DNA damage have been linked to both positive and negative alterations in telomere length and integrity. Here we examined how the common oxidative lesion 8-oxo-7,8-dihydro-2′-deoxyguanine (8-oxoG) re...

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Detalles Bibliográficos
Autores principales: Fouquerel, Elise, Lormand, Justin, Bose, Arindam, Lee, Hui-Ting, Kim, Grace S., Li, Jianfeng, Sobol, Robert W., Freudenthal, Bret D., Myong, Sua, Opresko, Patricia L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140714/
https://www.ncbi.nlm.nih.gov/pubmed/27820808
http://dx.doi.org/10.1038/nsmb.3319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140714/
https://www.ncbi.nlm.nih.gov/pubmed/27820808
http://dx.doi.org/10.1038/nsmb.3319

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