The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation

Flap endonuclease-1 (FEN1) is a multifunctional, structure-specific nuclease that has a critical role in maintaining human genome stability. FEN1 mutations have been detected in human cancer specimens and have been suggested to cause genomic instability and cancer predisposition. However, the exact...

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Detalles Bibliográficos
Autores principales: Sun, H, He, L, Wu, H, Pan, F, Wu, X, Zhao, J, Hu, Z, Sekhar, C, Li, H, Zheng, L, Chen, H, Shen, B H, Guo, Z
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140775/
https://www.ncbi.nlm.nih.gov/pubmed/27270424
http://dx.doi.org/10.1038/onc.2016.188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140775/
https://www.ncbi.nlm.nih.gov/pubmed/27270424
http://dx.doi.org/10.1038/onc.2016.188

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