A TGFβ-PRMT5-MEP50 Axis Regulates Cancer Cell Invasion through Histone H3 and H4 Arginine Methylation Coupled Transcriptional Activation and Repression

Protein arginine methyltransferase 5 (PRMT5) complexed with MEP50/WDR77 catalyzes arginine methylation on histones and other proteins. PRMT5-MEP50 activity is elevated in cancer cells and its expression is highly correlated with poor prognosis in many human tumors. We demonstrate that PRMT5-MEP50 is...

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Detalles Bibliográficos
Autores principales: Chen, Hongshan, Lorton, Benjamin, Gupta, Varun, Shechter, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140780/
https://www.ncbi.nlm.nih.gov/pubmed/27270440
http://dx.doi.org/10.1038/onc.2016.205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140780/
https://www.ncbi.nlm.nih.gov/pubmed/27270440
http://dx.doi.org/10.1038/onc.2016.205

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