Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism

Cellular senescence occurs by proliferative exhaustion (PEsen) or following multiple cellular stresses but had not previously been subject to detailed metabolomic analysis. Therefore, we compared PEsen fibroblasts with proliferating and transiently growth arrested controls using a combination of dif...

Descripción completa

Detalles Bibliográficos
Autores principales: James, Emma L., Lane, James A. E., Michalek, Ryan D., Karoly, Edward D., Parkinson, E. Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141431/
https://www.ncbi.nlm.nih.gov/pubmed/27924925
http://dx.doi.org/10.1038/srep38489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141431/
https://www.ncbi.nlm.nih.gov/pubmed/27924925
http://dx.doi.org/10.1038/srep38489

Ejemplares similares