Activation induced deaminase mutational signature overlaps with CpG methylation sites in follicular lymphoma and other cancers

Follicular lymphoma (FL) is an uncurable cancer characterized by progressive severity of relapses. We analyzed sequence context specificity of mutations in the B cells from a large cohort of FL patients. We revealed substantial excess of mutations within a novel hybrid nucleotide motif: the signatur...

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Detalles Bibliográficos
Autores principales: Rogozin, Igor B., Lada, Artem G., Goncearenco, Alexander, Green, Michael R., De, Subhajyoti, Nudelman, German, Panchenko, Anna R., Koonin, Eugene V., Pavlov, Youri I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141443/
https://www.ncbi.nlm.nih.gov/pubmed/27924834
http://dx.doi.org/10.1038/srep38133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141443/
https://www.ncbi.nlm.nih.gov/pubmed/27924834
http://dx.doi.org/10.1038/srep38133

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