Cargando…

Activation induced deaminase mutational signature overlaps with CpG methylation sites in follicular lymphoma and other cancers

Follicular lymphoma (FL) is an uncurable cancer characterized by progressive severity of relapses. We analyzed sequence context specificity of mutations in the B cells from a large cohort of FL patients. We revealed substantial excess of mutations within a novel hybrid nucleotide motif: the signatur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rogozin, Igor B., Lada, Artem G., Goncearenco, Alexander, Green, Michael R., De, Subhajyoti, Nudelman, German, Panchenko, Anna R., Koonin, Eugene V., Pavlov, Youri I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141443/ https://www.ncbi.nlm.nih.gov/pubmed/27924834 http://dx.doi.org/10.1038/srep38133

Ejemplares similares

AID/APOBEC cytosine deaminase induces genome-wide kataegis
por: Lada, Artem G, et al.
Publicado: (2012)

Replication Protein A (RPA) Hampers the Processive Action of APOBEC3G Cytosine Deaminase on Single-Stranded DNA
por: Lada, Artem G., et al.
Publicado: (2011)

Recombination Is Responsible for the Increased Recovery of Drug-Resistant Mutants with Hypermutated Genomes in Resting Yeast Diploids Expressing APOBEC Deaminases
por: Lada, Artem G., et al.
Publicado: (2017)

Nucleotide Weight Matrices Reveal Ubiquitous Mutational Footprints of AID/APOBEC Deaminases in Human Cancer Genomes
por: Rogozin, Igor B., et al.
Publicado: (2019)

Genome-Wide Mutation Avalanches Induced in Diploid Yeast Cells by a Base Analog or an APOBEC Deaminase
por: Lada, Artem G., et al.
Publicado: (2013)

A highly conserved family of inactivated archaeal B family DNA polymerases
por: Rogozin, Igor B, et al.
Publicado: (2008)

Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol ε and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors
por: Tahirov, Tahir H, et al.
Publicado: (2009)

Exploring background mutational processes to decipher cancer genetic heterogeneity
por: Goncearenco, Alexander, et al.
Publicado: (2017)

DNA Methylation, Deamination, and Translesion Synthesis Combine to Generate Footprint Mutations in Cancer Driver Genes in B-Cell Derived Lymphomas and Other Cancers
por: Rogozin, Igor B., et al.
Publicado: (2021)

Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes
por: Lada, Artem G., et al.
Publicado: (2015)

Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems
por: Iyer, Lakshminarayan M., et al.
Publicado: (2011)

Preservation of methylated CpG dinucleotides in human CpG islands
por: Panchin, Alexander Y., et al.
Publicado: (2016)

Methyl-CpG-binding protein 2 mediates overlapping mechanisms across brain disorders
por: Bach, Snow, et al.
Publicado: (2020)

QUFIND: tool for comparative prediction and mining of G4 quadruplexes overlapping with CpG islands
por: Kaur, Baljeet, et al.
Publicado: (2023)

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases
por: Arand, Julia, et al.
Publicado: (2012)

Polymorphism of Saccharomyces cerevisiae Strains in DNA Metabolism Genes
por: Zhuk, Anna S., et al.
Publicado: (2023)

Suppressive CpG
por: Van Epps, Heather L.
Publicado: (2005)

Factors to preserve CpG-rich sequences in methylated CpG islands
por: Miyahara, Hiroki, et al.
Publicado: (2015)

Getting positive about selection
por: Koonin, Eugene V, et al.
Publicado: (2003)

A Method for Identification of the Methylation Level of CpG Islands From NGS Data
por: Uroshlev, Leonid A., et al.
Publicado: (2020)

CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain Function
por: Jang, Hyun Sik, et al.
Publicado: (2017)

Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites
por: Grandi, Fiorella C., et al.
Publicado: (2015)

Prediction of CpG-island function: CpG clustering vs. sliding-window methods
por: Hackenberg, Michael, et al.
Publicado: (2010)

CpG Methylation Altered the Stability and Structure of the i-Motifs Located in the CpG Islands
por: Oshikawa, Daiki, et al.
Publicado: (2022)

CpGIF: an algorithm for the identification of CpG islands
por: Sujuan, Ye, et al.
Publicado: (2008)

The Effects of O(6)-methyl Guanine DNA-methyl Transferase Promotor Methylation and CpG1, CpG2, CpG3 and CpG4 Methylation on Treatment Response and their Prognostic Significance in Patients with Glioblastoma
por: Yildiz, OG, et al.
Publicado: (2020)

A Detailed History of Intron-rich Eukaryotic Ancestors Inferred from a Global Survey of 100 Complete Genomes
por: Csuros, Miklos, et al.
Publicado: (2011)

Impairment of translation in neurons as a putative causative factor for autism
por: Poliakov, Eugenia, et al.
Publicado: (2014)

MitoCOGs: clusters of orthologous genes from mitochondria and implications for the evolution of eukaryotes
por: Kannan, Sivakumar, et al.
Publicado: (2014)

Selection on start codons in prokaryotes and potential compensatory nucleotide substitutions
por: Belinky, Frida, et al.
Publicado: (2017)

The Control Region of Mitochondrial DNA Shows an Unusual CpG and Non-CpG Methylation Pattern
por: Bellizzi, Dina, et al.
Publicado: (2013)

Evaluation of single CpG sites as proxies of CpG island methylation states at the genome scale
por: Barrera, Víctor, et al.
Publicado: (2012)

Low biological fluctuation of mitochondrial CpG and non-CpG methylation at the single-molecule level
por: Goldsmith, Chloe, et al.
Publicado: (2021)

CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome
por: Heisler, Lawrence E., et al.
Publicado: (2005)

Bidding the CpG island goodbye
por: Greally, John M
Publicado: (2013)

CpG oligodeoxynucleotides as mucosal adjuvants
por: Iho, Sumiko, et al.
Publicado: (2015)

CpGPAP: CpG island predictor analysis platform
por: Chuang, Li-Yeh, et al.
Publicado: (2012)

Compensatory relationship between splice sites and exonic splicing signals depending on the length of vertebrate introns
por: Dewey, Colin N, et al.
Publicado: (2006)

Insertions in SARS-CoV-2 genome caused by template switch and duplications give rise to new variants that merit monitoring
por: Garushyants, Sofya K., et al.
Publicado: (2021)

Template switching and duplications in SARS-CoV-2 genomes give rise to insertion variants that merit monitoring
por: Garushyants, Sofya K., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_cjkq4l281hmkja1e87drvgka6p