Preclinical and Early Clinical Profile of a Highly Selective and Potent Oral Inhibitor of Aldosterone Synthase (CYP11B2)

Primary hyperaldosteronism is a common cause of resistant hypertension. Aldosterone is produced in the adrenal by aldosterone synthase (AS, encoded by the gene CYP11B2). AS shares 93% homology to 11β-hydroxylase (encoded by the gene CYP11B1), responsible for cortisol production. This homology has hi...

Descripción completa

Detalles Bibliográficos
Autores principales: Bogman, Katrijn, Schwab, Dietmar, Delporte, Marie-Laure, Palermo, Giuseppe, Amrein, Kurt, Mohr, Susanne, De Vera Mudry, Maria Cristina, Brown, Morris J., Ferber, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott, Williams & Wilkins 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142369/
https://www.ncbi.nlm.nih.gov/pubmed/27872236
http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.07716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142369/
https://www.ncbi.nlm.nih.gov/pubmed/27872236
http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.07716

Ejemplares similares