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Preclinical and Early Clinical Profile of a Highly Selective and Potent Oral Inhibitor of Aldosterone Synthase (CYP11B2)

Primary hyperaldosteronism is a common cause of resistant hypertension. Aldosterone is produced in the adrenal by aldosterone synthase (AS, encoded by the gene CYP11B2). AS shares 93% homology to 11β-hydroxylase (encoded by the gene CYP11B1), responsible for cortisol production. This homology has hi...

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Detalles Bibliográficos
Autores principales:	Bogman, Katrijn, Schwab, Dietmar, Delporte, Marie-Laure, Palermo, Giuseppe, Amrein, Kurt, Mohr, Susanne, De Vera Mudry, Maria Cristina, Brown, Morris J., Ferber, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott, Williams & Wilkins 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142369/ https://www.ncbi.nlm.nih.gov/pubmed/27872236 http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.07716

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