Impact of intravenous infusion time on AAV8 vector pharmacokinetics, safety, and liver transduction in cynomolgus macaques

Systemically delivered adeno-associated viral (AAV) vectors are now in early-phase clinical trials for a variety of diseases. While there is a general consensus on inclusion and exclusion criteria for each of these trials, the conditions under which vectors are infused vary significantly. In this st...

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Detalles Bibliográficos
Autores principales: Greig, Jenny A, Nordin, Jayme ML, Bote, Erin, Makaron, Leah, Garnett, Mason E, Kattenhorn, Lisa M, Bell, Peter, Goode, Tamara, Wilson, James M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142508/
https://www.ncbi.nlm.nih.gov/pubmed/27933307
http://dx.doi.org/10.1038/mtm.2016.79

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142508/
https://www.ncbi.nlm.nih.gov/pubmed/27933307
http://dx.doi.org/10.1038/mtm.2016.79

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