Dynamics of antigen presentation to transgene product-specific CD4(+) T cells and of Treg induction upon hepatic AAV gene transfer

The tolerogenic hepatic microenvironment impedes clearance of viral infections but is an advantage in viral vector gene transfer, which often results in immune tolerance induction to transgene products. Although the underlying tolerance mechanism has been extensively studied, our understanding of an...

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Detalles Bibliográficos
Autores principales: Perrin, George Q, Zolotukhin, Irene, Sherman, Alexandra, Biswas, Moanaro, de Jong, Ype P, Terhorst, Cox, Davidoff, Andrew M, Herzog, Roland W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142511/
https://www.ncbi.nlm.nih.gov/pubmed/27933310
http://dx.doi.org/10.1038/mtm.2016.83

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142511/
https://www.ncbi.nlm.nih.gov/pubmed/27933310
http://dx.doi.org/10.1038/mtm.2016.83

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