Tailored transgene expression to specific cell types in the central nervous system after peripheral injection with AAV9

The capacity of certain adeno-associated virus (AAV) vectors to cross the blood–brain barrier after intravenous delivery offers a unique opportunity for noninvasive brain delivery. However, without a well-tailored system, the use of a peripheral route injection may lead to undesirable transgene expr...

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Detalles Bibliográficos
Autores principales: Dashkoff, Jonathan, Lerner, Eli P, Truong, Nhi, Klickstein, Jacob A, Fan, Zhanyun, Mu, Dakai, Maguire, Casey A, Hyman, Bradley T, Hudry, Eloise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142512/
https://www.ncbi.nlm.nih.gov/pubmed/27933308
http://dx.doi.org/10.1038/mtm.2016.81

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142512/
https://www.ncbi.nlm.nih.gov/pubmed/27933308
http://dx.doi.org/10.1038/mtm.2016.81

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