Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation

Inflammasomes are cytosolic multi-protein complexes that initiate immune responses to infection by recruiting and activating the Caspase-1 protease. Human NLRP1 was the first protein shown to form an inflammasome, but its physiological mechanism of activation remains unknown. Recently, specific vari...

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Detalles Bibliográficos
Autores principales: Chavarría-Smith, Joseph, Mitchell, Patrick S., Ho, Alvin M., Daugherty, Matthew D., Vance, Russell E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142783/
https://www.ncbi.nlm.nih.gov/pubmed/27926929
http://dx.doi.org/10.1371/journal.ppat.1006052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142783/
https://www.ncbi.nlm.nih.gov/pubmed/27926929
http://dx.doi.org/10.1371/journal.ppat.1006052

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