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Inflammasome-Independent NLRP3 Restriction of a Protective Early Neutrophil Response to Pulmonary Tularemia

Francisella tularensis (Ft) causes a frequently fatal, acute necrotic pneumonia in humans and animals. Following lethal Ft infection in mice, infiltration of the lungs by predominantly immature myeloid cells and subsequent myeloid cell death drive pathogenesis and host mortality. However, following...

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Detalles Bibliográficos
Autores principales: Periasamy, Sivakumar, Le, Hongnga T., Duffy, Ellen B., Chin, Heather, Harton, Jonathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142794/
https://www.ncbi.nlm.nih.gov/pubmed/27926940
http://dx.doi.org/10.1371/journal.ppat.1006059