A single splice site mutation in human-specific ARHGAP11B causes basal progenitor amplification

The gene ARHGAP11B promotes basal progenitor amplification and is implicated in neocortex expansion. It arose on the human evolutionary lineage by partial duplication of ARHGAP11A, which encodes a Rho guanosine triphosphatase–activating protein (RhoGAP). However, a lack of 55 nucleotides in ARHGAP11...

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Detalles Bibliográficos
Autores principales: Florio, Marta, Namba, Takashi, Pääbo, Svante, Hiller, Michael, Huttner, Wieland B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142801/
https://www.ncbi.nlm.nih.gov/pubmed/27957544
http://dx.doi.org/10.1126/sciadv.1601941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142801/
https://www.ncbi.nlm.nih.gov/pubmed/27957544
http://dx.doi.org/10.1126/sciadv.1601941

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