The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances

Gene expression often requires interaction between promoters and distant enhancers, which occur within the context of highly organized topologically associating domains (TADs). Using a series of engineered chromosomal rearrangements at the Shh locus, we carried out an extensive fine-scale characteri...

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Detalles Bibliográficos
Autores principales: Symmons, Orsolya, Pan, Leslie, Remeseiro, Silvia, Aktas, Tugce, Klein, Felix, Huber, Wolfgang, Spitz, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142843/
https://www.ncbi.nlm.nih.gov/pubmed/27867070
http://dx.doi.org/10.1016/j.devcel.2016.10.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142843/
https://www.ncbi.nlm.nih.gov/pubmed/27867070
http://dx.doi.org/10.1016/j.devcel.2016.10.015

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