Cargando…

AB317. SPR-44 Pharmacological activation of individual KCNQ channel subtypes in detrusor smooth muscle represents a promising novel approach for overactive bladder treatment

OBJECTIVE: Our recent studies have demonstrated voltage-gated KCNQ channels (KCNQ1-KCNQ5) as key regulators of detrusor smooth muscle (DSM) function. Despite emerging developments, the physiological role of individual KCNQ channel subtypes remains less clear. Here, we utilized the novel compound ML-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Provence, Aaron, Angoli, Damiano, Petkov, Georgi V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2016
Materias:	Abstract
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143272/ http://dx.doi.org/10.21037/tau.2016.s317

Ejemplares similares

AB321. SPR-48 The effects of myrbetriq on detrusor overactivity associated with suprasacral spinal cord injury (SCI) in rats
por: Brooks, Jillene M., et al.
Publicado: (2016)

AB315. SPR-42 Cyclophosphamide-induced overactive bladder via downregulation of relaxation factors in detrusor PDGFRα(+) cells
por: Lee, Haeyeong, et al.
Publicado: (2016)

Regulation of Guinea Pig Detrusor Smooth Muscle Excitability by 17β-Estradiol: The Role of the Large Conductance Voltage- and Ca(2+)-Activated K(+) Channels
por: Provence, Aaron, et al.
Publicado: (2015)

Nongenomic modulation of the large conductance voltage‐ and Ca(2+)‐activated K(+) channels by estrogen: A novel regulatory mechanism in human detrusor smooth muscle
por: Hristov, Kiril L., et al.
Publicado: (2017)

AB297. SPR-24 Spinal cord injury and detrusor PDGFRα(+) cells
por: Lee, Haeyeong, et al.
Publicado: (2016)

AB206. Combined detrusor-trigone BTX-A injections for urinary incontinence secondary to neurogenic detrusor overactivity
por: Chen, Hui, et al.
Publicado: (2016)

AB319. SPR-46 In vivo hypogastric nerve electrical stimulation contracts the canine detrusor
por: Tiwari, Ekta, et al.
Publicado: (2016)

Investigating Urine Biomarkers in Detrusor Underactivity and Detrusor Overactivity with Detrusor Underactivity Patients
por: Jiang, Yuan-Hong, et al.
Publicado: (2023)

Urodynamic Detrusor Overactivity in Patients with Overactive Bladder Symptoms
por: Al-Ghazo, Mohammed A., et al.
Publicado: (2011)

AB292. SPR-19 Metabolomics provides novel insights into the effect of diabetes on bladder detrusor and urothelial metabolism
por: Wang, Yi, et al.
Publicado: (2016)

Botulinum Toxin in Neurogenic Detrusor Overactivity
por: D'Ancona, Carlos Arturo Levi, et al.
Publicado: (2012)

Detrusor Smooth Muscle K(V)7 Channels: Emerging New Regulators of Urinary Bladder Function
por: Malysz, John, et al.
Publicado: (2020)

Pharmacokinetics of solifenacin in pediatric populations with overactive bladder or neurogenic detrusor overactivity
por: Tannenbaum, Stacey, et al.
Publicado: (2020)

Alterations of the Myovesical Plexus of the Human Overactive Detrusor
por: Kuijpers, Kamiel A. J., et al.
Publicado: (2014)

Role of detrusor PDGFRα(+) cells in mouse model of cyclophosphamide-induced detrusor overactivity
por: Lee, Haeyeong, et al.
Publicado: (2022)

Coexisting overactive–underactive bladder and detrusor overactivity–underactivity in pelvic organ prolapse
por: Frigerio, Matteo, et al.
Publicado: (2022)

Neurogenic Detrusor Overactivity Is Associated with Decreased Expression and Function of the Large Conductance Voltage- and Ca(2+)-Activated K(+) Channels
por: Hristov, Kiril L., et al.
Publicado: (2013)

AB259. TRPV1 receptor associated with detrusor overactivity induced by partial bladder outlet obstruction in rats
por: Zhang, Zhaocun, et al.
Publicado: (2016)

AB099. Improvement of persistent detrusor overactivity after relief of bladder outlet obstruction treated by phytotherapeutic agent
por: Bae, Woong Jin, et al.
Publicado: (2017)

Combined detrusor-trigone BTX-A injections for urinary incontinence secondary to neurogenic detrusor overactivity
por: Hui, C, et al.
Publicado: (2016)

Autonomous Nervous System Activity in Women with Detrusor Overactivity
por: Im, Hyun Wook, et al.
Publicado: (2010)

Urinary nerve growth factor in patients with detrusor overactivity
por: Korzeniecka-Kozerska, A., et al.
Publicado: (2014)

OnabotulinumtoxinA for the treatment of neurogenic detrusor overactivity in children
por: Austin, Paul F., et al.
Publicado: (2020)

Increased detrusor collagen is associated with detrusor overactivity and decreased bladder compliance in men with benign prostatic obstruction
por: Bellucci, Carlos H.S., et al.
Publicado: (2017)

Preparation and Utilization of Freshly Isolated Human Detrusor Smooth Muscle Cells for Characterization of 9-Phenanthrol-Sensitive Cation Currents
por: Malysz, John, et al.
Publicado: (2020)

Activation of bitter taste receptors (tas2rs) relaxes detrusor smooth muscle and suppresses overactive bladder symptoms
por: Zhai, Kui, et al.
Publicado: (2016)

Urinary ATP May Be a Dynamic Biomarker of Detrusor Overactivity in Women with Overactive Bladder Syndrome
por: Silva-Ramos, Miguel, et al.
Publicado: (2013)

Differences in the Urinary Microbiome of Patients with Overactive Bladder Syndrome with and without Detrusor Overactivity on Urodynamic Measurements
por: Javan Balegh Marand, Aida, et al.
Publicado: (2023)

Treatment of neurogenic detrusor overactivity and overactive bladder with Botox (onabotulinumtoxinA): Development, insights, and impact
por: Nitti, Victor, et al.
Publicado: (2023)

Clinical Outcome in Male Patients With Detrusor Overactivity With Impaired Contractility
por: Liu, Shuo, et al.
Publicado: (2014)

Flowmetry/pelvic floor electromyographic findings in patients with detrusor overactivity
por: Alizadeh, Farshid, et al.
Publicado: (2015)

The Botulinum Treatment of Neurogenic Detrusor Overactivity: The Double-Face of the Neurotoxin
por: Traini, Chiara, et al.
Publicado: (2019)

Coexistent Detrusor Overactivity-Underactivity in Patients with Pelvic Floor Disorders
por: Frigerio, Matteo, et al.
Publicado: (2022)

AB116. Role of the novel herbal formulation (WSY-1075) in a refractory detrusor overactivity due to bladder outlet obstruction
por: Bae, Woong Jin, et al.
Publicado: (2016)

Molecular and functional characterization of detrusor PDGFRα positive cells in spinal cord injury-induced detrusor overactivity
por: Lee, Ken, et al.
Publicado: (2021)

CONCOMITANT DETRUSOR AND EXTERNAL URETHRAL SPHINCTER BOTULINUM TOXIN-A INJECTIONS IN MALE SPINAL CORD INJURY PATIENTS WITH DETRUSOR OVERACTIVITY AND DETRUSOR SPHINCTER DYSSYNERGIA
por: HUANG, Yu-Hui, et al.
Publicado: (2022)

AB107. Effect of partial ureteral obstruction on the auto-rhythmicity and contractility of detrusor smooth muscle in rats
por: Wang, Jingqi
Publicado: (2016)

300 IU vs. 200 IU of OnabotulinumtoxinA for detrusor overactivity
por: Persu, Cristian
Publicado: (2014)

Inosine Improves Neurogenic Detrusor Overactivity following Spinal Cord Injury
por: Chung, Yeun Goo, et al.
Publicado: (2015)

Fourteen-day administration of corticosterone may induce detrusor overactivity symptoms
por: Wróbel, Andrzej, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_i6s91u8fb3m4f74tqhpiqei2l0