Cargando…

AMPKα Is Suppressed in Bladder Cancer through Macrophage-Mediated Mechanisms()()

Bladder cancer presents as either low- or high-grade disease, each with distinct mutational profiles; however, both display prominent mTORC1 activation. One major negative regulator of mTORC1 is AMPK, which is a critical metabolic regulator that suppresses cellular growth in response to metabolic st...

Descripción completa

Detalles Bibliográficos
Autores principales: Kopsiaftis, Stavros, Hegde, Poornima, Taylor, John A., Claffey, Kevin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143351/
https://www.ncbi.nlm.nih.gov/pubmed/27916296
http://dx.doi.org/10.1016/j.tranon.2016.07.007