Guttiferone K impedes cell cycle re-entry of quiescent prostate cancer cells via stabilization of FBXW7 and subsequent c-MYC degradation

Cell cycle re-entry by quiescent cancer cells is an important mechanism for cancer progression. While high levels of c-MYC expression are sufficient for cell cycle re-entry, the modality to block c-MYC expression, and subsequent cell cycle re-entry, is limited. Using reversible quiescence rendered b...

Descripción completa

Detalles Bibliográficos
Autores principales: Xi, Z, Yao, M, Li, Y, Xie, C, Holst, J, Liu, T, Cai, S, Lao, Y, Tan, H, Xu, H-X, Dong, Q
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143372/
https://www.ncbi.nlm.nih.gov/pubmed/27253416
http://dx.doi.org/10.1038/cddis.2016.123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143372/
https://www.ncbi.nlm.nih.gov/pubmed/27253416
http://dx.doi.org/10.1038/cddis.2016.123

Ejemplares similares