Cargando…

BDNF pro-peptide regulates dendritic spines via caspase-3

The precursor of brain-derived neurotrophic factor (BDNF) (proBDNF) is enzymatically cleaved, by either intracellular (furin/PC1) or extracellular proteases (tPA/plasmin/MMP), to generate mature BDNF (mBDNF) and its pro-peptide (BDNF pro-peptide). Little is known about the function of BDNF pro-pepti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, J, Ji, Y, Ding, Y, Jiang, W, Sun, Y, Lu, B, Nagappan, G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143394/ https://www.ncbi.nlm.nih.gov/pubmed/27310873 http://dx.doi.org/10.1038/cddis.2016.166

Ejemplares similares

BDNF signaling during the lifetime of dendritic spines
por: Zagrebelsky, Marta, et al.
Publicado: (2020)

Pro-BDNF–induced synaptic depression and retraction at developing neuromuscular synapses
por: Yang, Feng, et al.
Publicado: (2009)

Extracellular and intracellular cleavages of proBDNF required at two distinct stages of late-phase LTP
por: Pang, Petti T, et al.
Publicado: (2016)

Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival
por: Koshimizu, Hisatsugu, et al.
Publicado: (2009)

KCC2 Regulates Dendritic Spine Formation in a Brain-Region Specific and BDNF Dependent Manner
por: Awad, Patricia Nora, et al.
Publicado: (2018)

The BDNF effects on dendritic spines of mature hippocampal neurons depend on neuronal activity
por: Kellner, Yves, et al.
Publicado: (2014)

Altered expression of BDNF, BDNF pro-peptide and their precursor proBDNF in brain and liver tissues from psychiatric disorders: rethinking the brain–liver axis
por: Yang, B, et al.
Publicado: (2017)

Platelets Selectively Regulate the Release of BDNF, But Not That of Its Precursor Protein, proBDNF
por: Le Blanc, Jessica, et al.
Publicado: (2020)

Caspase-1-Like Regulation of the proPO-System and Role of ppA and Caspase-1-Like Cleaved Peptides from proPO in Innate Immunity
por: Jearaphunt, Miti, et al.
Publicado: (2014)

BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met
por: Mizui, Toshiyuki, et al.
Publicado: (2015)

Caspase inhibition rescues F1Fo ATP synthase dysfunction-mediated dendritic spine elimination
por: Chen, Hao, et al.
Publicado: (2020)

Opposing presynaptic roles of BDNF and ProBDNF in the regulation of persistent activity in the entorhinal cortex
por: Gibon, Julien, et al.
Publicado: (2016)

Correction: Caspase-1-Like Regulation of the proPO-System and Role of ppA and Caspase-1-Like Cleaved Peptides from proPO in Innate Immunity
por: Jearaphunt, Miti, et al.
Publicado: (2016)

Divergent Roles of p75(NTR) and Trk Receptors in BDNF's Effects on Dendritic Spine Density and Morphology
por: Chapleau, Christopher A., et al.
Publicado: (2012)

Axin Regulates Dendritic Spine Morphogenesis through Cdc42-Dependent Signaling
por: Chen, Yu, et al.
Publicado: (2015)

Cdk5 Is Involved in BDNF-Stimulated Dendritic Growth in Hippocampal Neurons
por: Cheung, Zelda H, et al.
Publicado: (2007)

Caspase-2 is required for dendritic spine and behavioral alterations in J20 APP transgenic mice
por: Pozueta, Julio, et al.
Publicado: (2013)

BDNF pro-peptide: a novel synaptic modulator generated as an N-terminal fragment from the BDNF precursor by proteolytic processing
por: Mizui, Toshiyuki, et al.
Publicado: (2017)

miR-874 regulates myocardial necrosis by targeting caspase-8
por: Wang, K, et al.
Publicado: (2013)

Proteolysis of proBDNF Is a Key Regulator in the Formation of Memory
por: Barnes, Philip, et al.
Publicado: (2008)

Serum pro-BDNF/BDNF as a treatment biomarker for response to docosahexaenoic acid in traumatized people vulnerable to developing psychological distress: a randomized controlled trial
por: Matsuoka, Y, et al.
Publicado: (2015)

Caldendrin and myosin V regulate synaptic spine apparatus localization via ER stabilization in dendritic spines
por: Konietzny, Anja, et al.
Publicado: (2021)

BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons
por: Dieni, Sandra, et al.
Publicado: (2012)

Treadmill exercise suppressed stress-induced dendritic spine elimination in mouse barrel cortex and improved working memory via BDNF/TrkB pathway
por: Chen, K, et al.
Publicado: (2017)

Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF
por: Choi, Se Hoon, et al.
Publicado: (2009)

The primate-specific peptide Y-P30 regulates morphological maturation of neocortical dendritic spines
por: Neumann, Janine R., et al.
Publicado: (2019)

PS200. Effects of p11 on BDNF-induced changes in dendritic outgrowth and spine formation in primary hippocampal cells
por: Seo, Mi Kyoung, et al.
Publicado: (2016)

Decrease in the Ratio proBDNF/BDNF in the Urine of Aging Female Patients with OAB
por: Covarrubias, Claudia, et al.
Publicado: (2023)

Dendritic targeting of short and long 3′ UTR BDNF mRNA is regulated by BDNF or NT-3 and distinct sets of RNA-binding proteins
por: Vicario, Annalisa, et al.
Publicado: (2015)

A Novel Peptide Interfering with proBDNF-Sortilin Interaction Alleviates Chronic Inflammatory Pain
por: Ho, Idy H.T., et al.
Publicado: (2019)

Dendritic Spines as Tunable Regulators of Synaptic Signals
por: Tønnesen, Jan, et al.
Publicado: (2016)

p75NTR/proBDNF Modulates Basal Cell Carcinoma (BCC) Immune Microenvironment via Necroptosis Signaling Pathway
por: Lu, Qingli, et al.
Publicado: (2021)

Modulation of dendritic spine development and plasticity by BDNF and vesicular trafficking: fundamental roles in neurodevelopmental disorders associated with mental retardation and autism
por: Chapleau, Christopher A., et al.
Publicado: (2009)

Degradation of Postsynaptic Scaffold GKAP and Regulation of Dendritic Spine Morphology by the TRIM3 Ubiquitin Ligase in Rat Hippocampal Neurons
por: Hung, Albert Y., et al.
Publicado: (2010)

Role of BDNF/ProBDNF Imbalance in Postoperative Cognitive Dysfunction by Modulating Synaptic Plasticity in Aged Mice
por: Xue, Ziyi, et al.
Publicado: (2022)

Among Adolescents, BDNF and Pro-BDNF Lasting Changes with Alcohol Use Are Stage Specific
por: Miguez, Maria Jose, et al.
Publicado: (2020)

BDNF and Pro-BDNF in Amyotrophic Lateral Sclerosis: A New Perspective for Biomarkers of Neurodegeneration
por: Riolo, Giulia, et al.
Publicado: (2022)

BDNF, proBDNF and IGF-1 serum levels in naïve and medicated subjects with autism
por: Robinson-Agramonte, Maria de los Angeles, et al.
Publicado: (2022)

BDNF Facilitates L-LTP Maintenance in the Absence of Protein Synthesis through PKMζ
por: Mei, Fan, et al.
Publicado: (2011)

Influence of Quadrato Motor Training on Salivary proNGF and proBDNF
por: Caserta, Micaela, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_vcm5oq1o5cdumu15siir0di22d