Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease

Mutations in PINK1 and PARKIN cause early-onset Parkinson's disease (PD), thought to be due to mitochondrial toxicity. Here, we show that in Drosophila pink1 and parkin mutants, defective mitochondria also give rise to endoplasmic reticulum (ER) stress signalling, specifically to the activation...

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Detalles Bibliográficos
Autores principales: Celardo, I, Costa, A C, Lehmann, S, Jones, C, Wood, N, Mencacci, N E, Mallucci, G R, Loh, S H Y, Martins, L M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143399/
https://www.ncbi.nlm.nih.gov/pubmed/27336715
http://dx.doi.org/10.1038/cddis.2016.173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143399/
https://www.ncbi.nlm.nih.gov/pubmed/27336715
http://dx.doi.org/10.1038/cddis.2016.173

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