Cargando…

Engineered adenovirus fiber shaft fusion homotrimer of soluble TRAIL with enhanced stability and antitumor activity

Successful cancer therapies aim to induce selective apoptosis in neoplastic cells. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered an attractive anticancer agent due to its tumor cell-specific cytotoxicity. However, earlier studies with recombinant TRAIL revealed many s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, J, Wang, L, Wang, Z, Wang, B, Zhu, R, Bi, J, Wu, J, Zhang, H, Wu, H, Yu, B, Kong, W, Yu, X
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143403/ https://www.ncbi.nlm.nih.gov/pubmed/27336718 http://dx.doi.org/10.1038/cddis.2016.177

Ejemplares similares

Enhancing the antitumor activity of an engineered TRAIL-coated oncolytic adenovirus for treating acute myeloid leukemia
por: Wang, Zixuan, et al.
Publicado: (2020)

NMR pseudocontact shifts in a symmetric protein homotrimer
por: Müntener, Thomas, et al.
Publicado: (2020)

Antitumor Activity of TRAIL Recombinant Adenovirus in Human Malignant Glioma Cells
por: Kim, Ki-Uk, et al.
Publicado: (2005)

Molecular Mechanism of Type I Collagen Homotrimer Resistance to Mammalian Collagenases
por: Han, Sejin, et al.
Publicado: (2010)

Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state
por: Bu, Wenting, et al.
Publicado: (2020)

Potent antitumoral activity of TRAIL through generation of tumor-targeted single-chain fusion proteins
por: Schneider, B, et al.
Publicado: (2010)

Synergistic antitumor effects of CDK inhibitor SNS-032 and an oncolytic adenovirus co-expressing TRAIL and Smac in pancreatic cancer
por: Ge, Yun, et al.
Publicado: (2017)

Homotrimer cavin1 interacts with caveolin1 to facilitate tumor growth and activate microglia through extracellular vesicles in glioma
por: Wang, Lin, et al.
Publicado: (2020)

Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice
por: Lee, Katie J., et al.
Publicado: (2022)

Biochemical and biophysical characterization of the reovirus cell attachment protein σ1: Evidence that it is a homotrimer
por: Strong, James E., et al.
Publicado: (1991)

Up State of the SARS-COV-2 Spike Homotrimer Favors an Increased Virulence for New Variants
por: Giron, Carolina Corrêa, et al.
Publicado: (2021)

Soluble TRAIL Concentration in Serum Is Elevated in People with Hypercholesterolemia
por: Cheng, Wen, et al.
Publicado: (2015)

Recombinant oncolytic adenovirus expressing a soluble PVR elicits long-term antitumor immune surveillance
por: Zhang, Hailin, et al.
Publicado: (2020)

Antitumor Activity of Ad-IU2, a Prostate-Specific Replication-Competent Adenovirus Encoding the Apoptosis Inducer, TRAIL
por: Jiménez, Juan Antonio, et al.
Publicado: (2009)

Improved antitumor activity of TRAIL fusion protein via formation of self-assembling nanoparticle
por: Huang, Kaizong, et al.
Publicado: (2017)

Mutation of the Fiber Shaft Heparan Sulphate Binding Site of a 5/3 Chimeric Adenovirus Reduces Liver Tropism
por: Koski, Anniina, et al.
Publicado: (2013)

Adenoviruses with an α(v)β integrin targeting moiety in the fiber shaft or the HI-loop increase tumor specificity without compromising antitumor efficacy in magnetic resonance imaging of colorectal cancer metastases
por: Lavilla-Alonso, Sergio, et al.
Publicado: (2010)

Blocking TRAIL-DR5 signaling pathway with soluble death receptor 5 fusion protein mitigates radiation-induced injury
por: Zhao, Danyang, et al.
Publicado: (2023)

Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity
por: Siegemund, M, et al.
Publicado: (2012)

Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site
por: Kalathiya, Umesh, et al.
Publicado: (2020)

Self-derived peptides from the SARS-CoV-2 spike glycoprotein disrupting shaping and stability of the homotrimer unit
por: Padariya, Monikaben, et al.
Publicado: (2022)

Protocol to prepare functional cellular nanovesicles with PD1 and TRAIL to boost antitumor response
por: Yu, Peiwen, et al.
Publicado: (2021)

A SIRPα‐Fc fusion protein enhances the antitumor effect of oncolytic adenovirus against ovarian cancer
por: Huang, Yao, et al.
Publicado: (2020)

Detection of three human adenovirus species in adults with acute respiratory infection in China
por: Guo, L., et al.
Publicado: (2011)

TRAIL-R1-Targeted CAR-T Cells Exhibit Dual Antitumor Efficacy
por: Nai, Yaru, et al.
Publicado: (2021)

Synergistic Anti-tumour Effects of Quercetin and Oncolytic Adenovirus expressing TRAIL in Human Hepatocellular Carcinoma
por: Zou, Hai, et al.
Publicado: (2018)

Targeting lung cancer stem-like cells with TRAIL gene armed oncolytic adenovirus
por: Yang, Yu, et al.
Publicado: (2015)

Antitumor Effects of Oncolytic Adenovirus-Carrying siRNA Targeting Potential Oncogene EphA3
por: Zhao, Yali, et al.
Publicado: (2015)

Tumor-targeted delivery of biologically active TRAIL protein
por: Zhang, H-Y, et al.
Publicado: (2010)

Canine Adenovirus 1 Isolation Bioinformatics Analysis of the Fiber
por: Wang, Ben, et al.
Publicado: (2022)

Role of Fiber Shaft Length in Tumor Targeting with Ad5/3 Vectors
por: Richter, Maximilian, et al.
Publicado: (2022)

Toosendanin demonstrates promising antitumor efficacy in osteosarcoma by targeting STAT3
por: Zhang, T, et al.
Publicado: (2017)

TRAIL in the Treatment of Cancer: From Soluble Cytokine to Nanosystems
por: Alizadeh Zeinabad, Hojjat, et al.
Publicado: (2022)

Activation of systemic antitumor immunity via TRAIL-induced apoptosis
por: James, Britnie R., et al.
Publicado: (2012)

Correction: Toosendanin demonstrates promising antitumor efficacy in osteosarcoma by targeting STAT3
por: Zhang, T., et al.
Publicado: (2019)

Efficacy of adenovirally expressed soluble TRAIL in human glioma organotypic slice culture and glioma xenografts
por: Liu, Y, et al.
Publicado: (2011)

A Two Fiber Bragg Gratings Sensing System to Monitor the Torque of Rotating Shaft
por: Wang, Yongjiao, et al.
Publicado: (2016)

Improvement of Pharmacokinetic Profile of TRAIL via Trimer-Tag Enhances its Antitumor Activity in vivo
por: Liu, Haipeng, et al.
Publicado: (2017)

Multi-Sensor Fusion and Error Compensation of Attitude Measurement System for Shaft Boring Machine
por: Wang, Xinliang, et al.
Publicado: (2019)

Efficient gene transfer into T lymphocytes by fiber-modified human adenovirus 5
por: Lv, Yun, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_kl7ffn2g3u0icod26ef5fjpdqo