A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity

BACKGROUND: Group B Neisseria meningitidis, an endotoxin-producing Gram-negative bacterium, causes the highest incidence of group B meningococcus (MenB) disease in the first year of life. The Bexsero vaccine is indicated in Europe from 8 weeks of age. Endotoxin components of outer membrane vesicles...

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Detalles Bibliográficos
Autores principales: Dowling, David J., Sanders, Holly, Cheng, Wing Ki, Joshi, Sweta, Brightman, Spencer, Bergelson, Ilana, Pietrasanta, Carlo, van Haren, Simon D., van Amsterdam, Sandra, Fernandez, Jeffrey, van den Dobbelsteen, Germie P. J. M., Levy, Ofer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143884/
https://www.ncbi.nlm.nih.gov/pubmed/28008331
http://dx.doi.org/10.3389/fimmu.2016.00562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143884/
https://www.ncbi.nlm.nih.gov/pubmed/28008331
http://dx.doi.org/10.3389/fimmu.2016.00562

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