Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation

We previously reported early and extensive loss of astrocytic connexin 43 (Cx43) in acute demyelinating lesions of multiple sclerosis (MS) patients. Because it is widely accepted that autoimmune T cells initiate MS lesions, we hypothesized that infiltrating T cells affect Cx43 expression in astrocyt...

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Detalles Bibliográficos
Autores principales: Watanabe, Mitsuru, Masaki, Katsuhisa, Yamasaki, Ryo, Kawanokuchi, Jun, Takeuchi, Hideyuki, Matsushita, Takuya, Suzumura, Akio, Kira, Jun-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143974/
https://www.ncbi.nlm.nih.gov/pubmed/27929069
http://dx.doi.org/10.1038/srep38387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143974/
https://www.ncbi.nlm.nih.gov/pubmed/27929069
http://dx.doi.org/10.1038/srep38387

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