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Artifactual mutations resulting from DNA lesions limit detection levels in ultrasensitive sequencing applications
The need in cancer research or evolutionary biology to detect rare mutations or variants present at very low frequencies (<10(−5)) poses an increasing demand on lowering the detection limits of available methods. Here we demonstrated that amplifiable DNA lesions introduce important error sources...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144678/ https://www.ncbi.nlm.nih.gov/pubmed/27477585 http://dx.doi.org/10.1093/dnares/dsw038 |