Structure–activity relationships study of mTOR kinase inhibition using QSAR and structure-based drug design approaches

The discovery of clinically relevant inhibitors of mammalian target of rapamycin (mTOR) for anticancer therapy has proved to be a challenging task. The quantitative structure–activity relationship (QSAR) approach is a very useful and widespread technique for ligand-based drug design, which can be us...

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Detalles Bibliográficos
Autores principales: Lakhlili, Wiame, Yasri, Abdelaziz, Ibrahimi, Azeddine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144904/
https://www.ncbi.nlm.nih.gov/pubmed/27980424
http://dx.doi.org/10.2147/OTT.S108526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144904/
https://www.ncbi.nlm.nih.gov/pubmed/27980424
http://dx.doi.org/10.2147/OTT.S108526

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