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Structure–activity relationships study of mTOR kinase inhibition using QSAR and structure-based drug design approaches
The discovery of clinically relevant inhibitors of mammalian target of rapamycin (mTOR) for anticancer therapy has proved to be a challenging task. The quantitative structure–activity relationship (QSAR) approach is a very useful and widespread technique for ligand-based drug design, which can be us...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Dove Medical Press
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144904/ https://www.ncbi.nlm.nih.gov/pubmed/27980424 http://dx.doi.org/10.2147/OTT.S108526 |