Ku Binding on Telomeres Occurs at Sites Distal from the Physical Chromosome Ends

The Ku complex binds non-specifically to DNA breaks and ensures repair via NHEJ. However, Ku is also known to bind directly to telomeric DNA ends and its presence there is associated with telomere capping, but avoiding NHEJ. How the complex discriminates between a DNA break and a telomeric extremity...

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Detalles Bibliográficos
Autores principales: Larcher, Mélanie V., Pasquier, Emeline, MacDonald, R. Stephen, Wellinger, Raymund J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145143/
https://www.ncbi.nlm.nih.gov/pubmed/27930670
http://dx.doi.org/10.1371/journal.pgen.1006479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145143/
https://www.ncbi.nlm.nih.gov/pubmed/27930670
http://dx.doi.org/10.1371/journal.pgen.1006479

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