Structural Mapping and Functional Characterization of Zebrafish Class B G-Protein Coupled Receptor (GPCR) with Dual Ligand Selectivity towards GLP-1 and Glucagon

GLP-1 and glucagon regulate glucose metabolism through a network of metabolic pathways initiated upon binding to their specific receptors that belong to class B G-protein coupled receptors (GPCRs). The therapeutic potential of glucagon is currently being evaluated, while GLP-1 is already used in the...

Description complète

Détails bibliographiques
Auteurs principaux: Oren, Deena A., Wei, Yang, Skrabanek, Luce, Chow, Billy K. C., Mommsen, Thomas, Mojsov, Svetlana
Format: Online Article Texte
Langue:English
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145181/
https://www.ncbi.nlm.nih.gov/pubmed/27930690
http://dx.doi.org/10.1371/journal.pone.0167718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145181/
https://www.ncbi.nlm.nih.gov/pubmed/27930690
http://dx.doi.org/10.1371/journal.pone.0167718

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