The Ebola Interferon Inhibiting Domains Attenuate and Dysregulate Cell-Mediated Immune Responses

Ebola virus (EBOV) infections are characterized by deficient T-lymphocyte responses, T-lymphocyte apoptosis and lymphopenia. We previously showed that disabling of interferon-inhibiting domains (IIDs) in the VP24 and VP35 proteins effectively unblocks maturation of dendritic cells (DCs) and increase...

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Detalles Bibliográficos
Autores principales: Lubaki, Ndongala Michel, Younan, Patrick, Santos, Rodrigo I., Meyer, Michelle, Iampietro, Mathieu, Koup, Richard A., Bukreyev, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145241/
https://www.ncbi.nlm.nih.gov/pubmed/27930745
http://dx.doi.org/10.1371/journal.ppat.1006031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145241/
https://www.ncbi.nlm.nih.gov/pubmed/27930745
http://dx.doi.org/10.1371/journal.ppat.1006031

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