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High Transmembrane Voltage Raised by Close Contact Initiates Fusion Pore

Membrane fusion lies at the heart of neuronal communication but the detailed mechanism of a critical step, fusion pore initiation, remains poorly understood. Here, through atomistic molecular dynamics simulations, a transient pore formation induced by a close contact of two apposed bilayers is first...

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Detalles Bibliográficos
Autores principales: Bu, Bing, Tian, Zhiqi, Li, Dechang, Ji, Baohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145871/
https://www.ncbi.nlm.nih.gov/pubmed/28018169
http://dx.doi.org/10.3389/fnmol.2016.00136