Short-term cytotoxic effects and long-term instability of RNAi delivered using lentiviral vectors

BACKGROUND: RNA interference (RNAi) can potently reduce target gene expression in mammalian cells and is in wide use for loss-of-function studies. Several recent reports have demonstrated that short double-stranded RNAs (dsRNAs), used to mediate RNAi, can also induce an interferon-based response res...

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Detalles Bibliográficos
Autores principales: Fish, Richard J, Kruithof, Egbert KO
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514603/
https://www.ncbi.nlm.nih.gov/pubmed/15291968
http://dx.doi.org/10.1186/1471-2199-5-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514603/
https://www.ncbi.nlm.nih.gov/pubmed/15291968
http://dx.doi.org/10.1186/1471-2199-5-9

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