Structure of the RBM7–ZCCHC8 core of the NEXT complex reveals connections to splicing factors

The eukaryotic RNA exosome participates extensively in RNA processing and degradation. In human cells, three accessory factors (RBM7, ZCCHC8 and hMTR4) interact to form the nuclear exosome targeting (NEXT) complex, which directs a subset of non-coding RNAs for exosomal degradation. Here we elucidate...

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Detalles Bibliográficos
Autores principales: Falk, Sebastian, Finogenova, Ksenia, Melko, Mireille, Benda, Christian, Lykke-Andersen, Søren, Jensen, Torben Heick, Conti, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146272/
https://www.ncbi.nlm.nih.gov/pubmed/27905398
http://dx.doi.org/10.1038/ncomms13573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146272/
https://www.ncbi.nlm.nih.gov/pubmed/27905398
http://dx.doi.org/10.1038/ncomms13573

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