L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling

Mounting in vitro, in vivo and clinical evidence suggest an important role for filopodia in driving cancer cell invasion. Using a high-throughput microscopic-based drug screen, we identify FDA-approved calcium channel blockers (CCBs) as potent inhibitors of filopodia formation in cancer cells. Unexp...

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Detalles Bibliográficos
Autores principales: Jacquemet, Guillaume, Baghirov, Habib, Georgiadou, Maria, Sihto, Harri, Peuhu, Emilia, Cettour-Janet, Pierre, He, Tao, Perälä, Merja, Kronqvist, Pauliina, Joensuu, Heikki, Ivaska, Johanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146291/
https://www.ncbi.nlm.nih.gov/pubmed/27910855
http://dx.doi.org/10.1038/ncomms13297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146291/
https://www.ncbi.nlm.nih.gov/pubmed/27910855
http://dx.doi.org/10.1038/ncomms13297

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