A single amino acid determines preference between phospholipids and reveals length restriction for activation ofthe S1P(4 )receptor

BACKGROUND: Sphingosine-1-phosphate and lysophosphatidic acid (LPA) are ligands for two related families of G protein-coupled receptors, the S1P and LPA receptors, respectively. The lysophospholipid ligands of these receptors are structurally similar, however recognition of these lipids by these rec...

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Detalles Bibliográficos
Autores principales: Holdsworth, Gill, Osborne, Daniel A, Pham, TrucChi Thi, Fells, James I, Hutchinson, Gillian, Milligan, Graeme, Parrill, Abby L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514652/
https://www.ncbi.nlm.nih.gov/pubmed/15298705
http://dx.doi.org/10.1186/1471-2091-5-12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514652/
https://www.ncbi.nlm.nih.gov/pubmed/15298705
http://dx.doi.org/10.1186/1471-2091-5-12

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