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PDGF-AA mediates mesenchymal stromal cell chemotaxis to the head and neck squamous cell carcinoma tumor microenvironment

BACKGROUND: The robust desmoplasia associated with head and neck squamous cell carcinoma (HNSCC) suggests that the tumor microenvironment may be an important component in the pathophysiology of this cancer. Moreover, the high recurrence rate and poor clinical response to chemotherapy and radiation t...

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Detalles Bibliográficos
Autores principales: Watts, Tammara L., Cui, Ruwen, Szaniszlo, Peter, Resto, Vicente A., Powell, Don W., Pinchuk, Irina V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146849/
https://www.ncbi.nlm.nih.gov/pubmed/27931212
http://dx.doi.org/10.1186/s12967-016-1091-6