Timosaponin AIII induces antiplatelet and antithrombotic activity via Gq-mediated signaling by the thromboxane A2 receptor

The thromboxane (Tx) A(2) pathway is a major contributor to the amplification of initial platelet activation and is therefore a key drug target. To identify potent small-molecule inhibitors of the thromboxane prostaglandin (TP) receptor, we screened a small steroidal saponin library using U46619-ind...

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Detalles Bibliográficos
Autores principales: Cong, Yue, Wang, Limei, Peng, Renjun, Zhao, Yang, Bai, Fan, Yang, Chao, Liu, Xiaolan, Wang, Daqian, Ma, Baiping, Cong, Yuwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146924/
https://www.ncbi.nlm.nih.gov/pubmed/27934923
http://dx.doi.org/10.1038/srep38757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146924/
https://www.ncbi.nlm.nih.gov/pubmed/27934923
http://dx.doi.org/10.1038/srep38757

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