Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout

Gouty arthritis is caused by the deposition of uric acid crystals, which induce the activation of NOD-like receptor family, pyrin domain containing 3(NLRP3) inflammasome. The NLRP3 inflammasome, composed of NLRP3, the adaptor protein ASC, and caspase-1, is closely linked to the pathogenesis of vario...

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Detalles Bibliográficos
Autores principales: Lee, Hye Eun, Yang, Gabsik, Kim, Nam Doo, Jeong, Seongkeun, Jung, Yunjin, Choi, Jae Young, Park, Hyun Ho, Lee, Joo Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146947/
https://www.ncbi.nlm.nih.gov/pubmed/27934918
http://dx.doi.org/10.1038/srep38622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146947/
https://www.ncbi.nlm.nih.gov/pubmed/27934918
http://dx.doi.org/10.1038/srep38622

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