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Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout

Gouty arthritis is caused by the deposition of uric acid crystals, which induce the activation of NOD-like receptor family, pyrin domain containing 3(NLRP3) inflammasome. The NLRP3 inflammasome, composed of NLRP3, the adaptor protein ASC, and caspase-1, is closely linked to the pathogenesis of vario...

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Detalles Bibliográficos
Autores principales:	Lee, Hye Eun, Yang, Gabsik, Kim, Nam Doo, Jeong, Seongkeun, Jung, Yunjin, Choi, Jae Young, Park, Hyun Ho, Lee, Joo Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146947/ https://www.ncbi.nlm.nih.gov/pubmed/27934918 http://dx.doi.org/10.1038/srep38622

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