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Postnatal activation of TLR4 in astrocytes promotes excitatory synaptogenesis in hippocampal neurons

Astrocytes are critical in synapse development, and their dysfunction in crucial developmental stages leads to serious neurodevelopmental diseases, including seizures and epilepsy. Immune challenges not only affect brain development, but also promote seizure generation and epileptogenesis, implying...

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Detalles Bibliográficos
Autores principales: Shen, Yi, Qin, Huaping, Chen, Juan, Mou, Lingyan, He, Yang, Yan, Yixiu, Zhou, Hang, Lv, Ya, Chen, Zhong, Wang, Junlu, Zhou, Yu-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147000/
https://www.ncbi.nlm.nih.gov/pubmed/27920126
http://dx.doi.org/10.1083/jcb.201605046