Combined Whole-Cell High-Throughput Functional Screening for Identification of New Nicotinamidases/Pyrazinamidases in Metagenomic/Polygenomic Libraries

Nicotinamidases catalyze the hydrolysis of the amide bond in nicotinamide (NAM) to produce ammonia and nicotinic acid (NA). These enzymes are an essential component of the NAD(+) salvage pathway and are implicated in the viability of several pathogenic organisms. Its absence in humans makes them a p...

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Detalles Bibliográficos
Autores principales: Zapata-Pérez, Rubén, García-Saura, Antonio G., Jebbar, Mohamed, Golyshin, Peter N., Sánchez-Ferrer, Álvaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147024/
https://www.ncbi.nlm.nih.gov/pubmed/28018295
http://dx.doi.org/10.3389/fmicb.2016.01915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147024/
https://www.ncbi.nlm.nih.gov/pubmed/28018295
http://dx.doi.org/10.3389/fmicb.2016.01915

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