mTORC1 signalling and eIF4E/4E-BP1 translation initiation factor stoichiometry influence recombinant protein productivity from GS-CHOK1 cells

Many protein-based biotherapeutics are produced in cultured Chinese hamster ovary (CHO) cell lines. Recent reports have demonstrated that translation of recombinant mRNAs and global control of the translation machinery via mammalian target of rapamycin (mTOR) signalling are important determinants of...

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Detalles Bibliográficos
Autores principales: Jossé, Lyne, Xie, Jianling, Proud, Christopher G., Smales, C. Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147049/
https://www.ncbi.nlm.nih.gov/pubmed/27760840
http://dx.doi.org/10.1042/BCJ20160845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147049/
https://www.ncbi.nlm.nih.gov/pubmed/27760840
http://dx.doi.org/10.1042/BCJ20160845

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