The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets

Human genome-wide association studies (GWAS) have shown that genetic variation at >130 gene loci is associated with type 2 diabetes (T2D). We asked if the expression of the candidate T2D-associated genes within these loci is regulated by a common locus in pancreatic islets. Using an obese F2 mous...

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Detalles Bibliográficos
Autores principales: Keller, Mark P., Paul, Pradyut K., Rabaglia, Mary E., Stapleton, Donnie S., Schueler, Kathryn L., Broman, Aimee Teo, Ye, Shuyun Isabella, Leng, Ning, Brandon, Christopher J., Neto, Elias Chaibub, Plaisier, Christopher L., Simonett, Shane P., Kebede, Melkam A., Sheynkman, Gloria M., Klein, Mark A., Baliga, Nitin S., Smith, Lloyd M., Broman, Karl W., Yandell, Brian S., Kendziorski, Christina, Attie, Alan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147809/
https://www.ncbi.nlm.nih.gov/pubmed/27935966
http://dx.doi.org/10.1371/journal.pgen.1006466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147809/
https://www.ncbi.nlm.nih.gov/pubmed/27935966
http://dx.doi.org/10.1371/journal.pgen.1006466

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