Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase

The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV replication. To investigate the ALLINI inhibitory m...

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Detalles Bibliográficos
Autores principales: Gupta, Kushol, Turkki, Vesa, Sherrill-Mix, Scott, Hwang, Young, Eilers, Grant, Taylor, Louis, McDanal, Charlene, Wang, Ping, Temelkoff, David, Nolte, Robert T., Velthuisen, Emile, Jeffrey, Jerry, Van Duyne, Gregory D., Bushman, Frederic D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147827/
https://www.ncbi.nlm.nih.gov/pubmed/27935939
http://dx.doi.org/10.1371/journal.pbio.1002584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147827/
https://www.ncbi.nlm.nih.gov/pubmed/27935939
http://dx.doi.org/10.1371/journal.pbio.1002584

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