Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase

The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV replication. To investigate the ALLINI inhibitory m...

Descripción completa

Detalles Bibliográficos
Autores principales: Gupta, Kushol, Turkki, Vesa, Sherrill-Mix, Scott, Hwang, Young, Eilers, Grant, Taylor, Louis, McDanal, Charlene, Wang, Ping, Temelkoff, David, Nolte, Robert T., Velthuisen, Emile, Jeffrey, Jerry, Van Duyne, Gregory D., Bushman, Frederic D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147827/
https://www.ncbi.nlm.nih.gov/pubmed/27935939
http://dx.doi.org/10.1371/journal.pbio.1002584

Ejemplares similares

Ejemplares similares