Tamoxifen Isomers and Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors: Potential Scaffold for Drug Development

Tamoxifen (Tam) is a selective estrogen receptor (ER) modulator (SERM) that is an essential drug to treat ER-positive breast cancer. Aside from known actions at ERs, recent studies have suggested that some SERMs like Tam also exhibit novel activity at cannabinoid subtype 1 and 2 receptors (CB1R and...

Descripción completa

Detalles Bibliográficos
Autores principales: Ford, Benjamin M., Franks, Lirit N., Radominska-Pandya, Anna, Prather, Paul L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147891/
https://www.ncbi.nlm.nih.gov/pubmed/27936172
http://dx.doi.org/10.1371/journal.pone.0167240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147891/
https://www.ncbi.nlm.nih.gov/pubmed/27936172
http://dx.doi.org/10.1371/journal.pone.0167240

Ejemplares similares