Epigallocatechin-3-Gallate Upregulates miR-221 to Inhibit Osteopontin-Dependent Hepatic Fibrosis

Osteopontin (OPN) promotes hepatic fibrosis, and developing therapies targeting OPN expression in settings of hepatic injury holds promise. The polyphenol epigallocatechin-3-gallate (EGCG), found in high concentrations in green tea, downregulates OPN expression through OPN mRNA degradation, but the...

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Detalles Bibliográficos
Autores principales: Arffa, M. L., Zapf, M. A., Kothari, A. N., Chang, V., Gupta, G. N., Ding, X., Al-Gayyar, M. M., Syn, W., Elsherbiny, N. M., Kuo, P. C., Mi, Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147893/
https://www.ncbi.nlm.nih.gov/pubmed/27935974
http://dx.doi.org/10.1371/journal.pone.0167435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147893/
https://www.ncbi.nlm.nih.gov/pubmed/27935974
http://dx.doi.org/10.1371/journal.pone.0167435

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